I am setting up an OS X 10.8 (Mountain Lion) machine as a development machine. For my own personal use I prefer using a Linux box, but between my own nostalgia for Gentoo and the peculiar yet undeniable strength of homebrew, I am perfectly happy to use it as a day-to-day development machine.
In order to use homebrew to its fullest, I edited the /etc/paths file to make things right:
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So far, no problems. Will report back later.